Association between rs۳۶۲۷۴۶ polymorphism of RELN and Schizophrenia in Iranian Patients

Genetic studies, there is a potential association of RELN with some psychologicaldisorders such as Autism Spectrum Disorders (ASD) schizophrenia (SCZ). The RELNgene is located on chromosome ۷q۲۲.۱ and encodes a large secretory protein of theextracellular matrix (Reelin). In the present case-control study, we intended to investigatethe relationship between the rs۳۶۲۷۴۶ polymorphism of RELN and schizophrenia in agroup of schizophrenic and healthy subjects from northeastern Iran.۳۰ unrelated schizophrenic patients and ۳۰ matched control subjects were recruited The samplesfrom the participants underwent PCR and sequencing for RELN genotype identification.he genotype distribution for  both study and control groups were not in Hardy–Weinberg equilibrium(P>۰.۰۵).However, it was found that the prevalence ofrs۳۶۲۷۴۶ polymorphism was significantly different between the groups. the present study supported the evidence that rs۳۶۲۷۴۶ polymorphism of RELN was agenetic factor for schizophrenia susceptibility. However, there is a need for replicationstudies on different populations and further investigations on the sex-specific associationof this gene with schizophrenia.

Keywords:

Schizophrenia , Reelin gene , single nucleotide polymorphism , Sequencing