Covid19 disease and the effect of genetic factors on its severity and weakness

Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV-2), is a severe infection with respiratory and systemicmanifestations. This infectious disease has a complex course and manifests itself withvarious clinical presentations, ranging from asymptomatic infection to a severe clinicalcourse. These variations in severity have raised the question of whether the genetic orepigenetic variations have a role in COVID-19 susceptibility or severity, and that thesefactors can be used to predict the disease course. A whole-genome sequencing performedon 95 samples of SARS-CoV-2 identified 116 unique mutations, most of which weremissense and synonymous. Moreover, some studies have reported a relationship betweenthe COVID-19 severity and the genes ACE and TMPRSS2. The present review providesan overview of different genes that have been found to be implicated or related to thesusceptibility to COVID-19 or its severity.

Covid19 disease and the effect of genetic factors on its severity and weakness Keywords:

Covid19 , ACE gene , TMPRSS2 gene , Infection