Synthesis and antibacterial activities of novel ۱-bromo-۲-(۶-bromo-۱,۲,۳,۴-tetrahydro-۹H-carbazol-۱-yl) ethanone and ۱-bromo-۲-(۵-bromo-۱,۲,۳-trihydrocyclopenta[b]indole-۱-yl) ethanone.

Nitrogen containing hetero cyclic compounds constitute the interior structure of a number of biologically attracted compounds against bacteria and fungi. The synthesis of carbazole derivatives have been desire due to their importance in medicinal field. Enhanced approach of Fischer’s synthesis followed by bromoacetylation have been used to synthesis four different carbazole derivatives, namely ۱-bromo-۲-(۶-bromo-۱,۲,۳,۴-tetrahydro-۹H-carbazol-۱-yl) ethanone, ۱-bromo-۲-(۵-bromo-۱,۲,۳-trihydrocyclopenta[b]indole-۱-yl) ethanone. The synthesized compounds were identified and confirmed using spectral techniques Viz, FTIR, ۱H NMR, ۱۳C NMR, MASS Spectroscopy. Antibacterial evaluation of synthesized compounds found to have pronozed antibacterial activity.Nitrogen containing hetero cyclic compounds constitute the interior structure of a number of biologically attracted compounds against bacteria and fungi. The synthesis of carbazole derivatives have been desire due to their importance in medicinal field. Enhanced approach of Fischer’s synthesis followed by bromoacetylation have been used to synthesis four different carbazole derivatives, namely ۱-bromo-۲-(۶-bromo-۱,۲,۳,۴-tetrahydro-۹H-carbazol-۱-yl) ethanone, ۱-bromo-۲-(۵-bromo-۱,۲,۳-trihydrocyclopenta[b]indole-۱-yl) ethanone. The synthesized compounds were identified and confirmed using spectral techniques Viz, FTIR, ۱H NMR, ۱۳C NMR, MASS Spectroscopy. Antibacterial evaluation of synthesized compounds found to have pronozed antibacterial activity.

Keywords:

Bromoacetyl bromide , Ciprofloxacin , novel carbazole