The Effect of Sleep Deprivation on the Association between Positive Affect and Resting-State Networks

IntroductionPrevious studies reported that individuals with sleep deprivation (SD) have a less positive affect(PA) than individuals with normal sleep [۱]. We aimed to compare the association between PA and resting-state networks after a night of normal sleep and partial SD for a better understanding the neural correlates of PA after SD.MethodsWe analyzed T۱-weighted and R-fMRI images of ۳۰ healthy subjects from the Stockholm Sleepy Brain study [۲]. In a cross-over design, two sessions were recorded after partial SD (۳h sleep) and normal sleep. The PA had been studied by PA subscale of positive and negative affect schedule[۳] after normal sleep or SD. Preprocessing was performed using DPARSF toolbox. Group independent component (IC) analysis was applied using the GIFT toolbox for each group. We performed transformation into PA score-first singular value space for each IC and mapped subjects’ IC features in this space. We measured the PA effect on resting-state integrity by linear regression in each condition. Finally, paired t-test analysis was performed by coding in MATLAB to find significantly different trends (p-value<۰.۰۵).ResultsResults showed that there were significant differences in the association between PA scores and integrity of the primary visual network, secondary visual network, default mode network (DMN), and left fronto-parietal network (Table۱ and Figure۱). The higher PA scores, the lower the integrity in primary and secondary visual networks after normal sleep. The higher PA, the higher the integrity in primary and secondary visual networks after SD. After normal sleep, individuals with higher PA had higher integrity in DMN and left fronto-parietal networks. After SD, individuals with higher PA had lower integrity in DMN and left fronto-parietal networks.ConclusionOur result shows that dysfunction in transferring data in the mentioned networks is associated with low PA after SD and suggest such dysfunction serves as specific psychopathology of SD.