Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 24، Issue: 8
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-24-8_016
تاریخ نمایه سازی: 10 شهریور 1400
Abstract:
Objective(s): Protective effects of s-methyl cysteine (SMC) alone, protocatechuic acid (PCA) alone, and SMC plus PCA against chronic ethanol consumption induced hepatic steatosis and inflammation were investigated. Materials and Methods: Mice were divided into six groups: normal diet (ND) group, Lieber-DeCarli liquid diet without ethanol (LD diet) group, LD diet with ethanol (LED diet) group, SMC group (LED diet plus ۰.۲۵% SMC), PCA group (LED diet plus ۰.۲۵% PCA), and SMC+PCA group (LED diet plus ۰.۱۲۵% SMC + ۰.۱۲۵% PCA). After ۸ weeks of supplementation, blood and liver were used for analysis. Results: Biochemical and histological data showed that SMC plus PCA led to a greater reduction in lipid droplets in the liver than SMC or PCA treatment alone. SMC plus PCA resulted in greater suppression in hepatic mRNA expression of peroxisome proliferator-activated receptor-gamma, sterol regulatory element-binding protein ۱c, stearoyl-CoA desaturase-۱, cyclooxygenase-۲, and myeloperoxidase than SMC or PCA treatment alone. SMC plus PCA led to a greater decrease in hepatic reactive oxygen species and inflammatory cytokine levels than SMC or PCA treatment alone. Conclusion: These novel findings suggest that the combination of SMC and PCA was a potent remedy for alcoholic liver disorders.
Keywords:
Ethanol Hepatic steatosis Myeloperoxidase Protocatechuic acid S , methyl cysteine
Authors
Chun-Che Lin
Center for Digestive Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan
Ya-Chen Yang
Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan
Chia-Yu Chen
Department of Gastroenterology, Asia University Hospital, Taichung, Taiwan
Mei-Chin Yin
Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan
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