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Title

CTLA-۴ Gene Haplotypes and the Risk of Chronic Hepatitis C Infection; a Case Control Study

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 6، شماره: 1
Year: 1396
COI: JR_RBMB-6-1_007
Language: EnglishView: 49
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Authors

Samaneh Sepahi - Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Alireza Pasdar - Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran - Division of Applied Medicine, Medical School, University of Aberdeen, Foresterhill, Aberdeen, AB۲۵ ۲ZD, UK.
Sina Gerayli - Department of Biology, University of Western Ontario, London, Ontario N۶A ۵B۷, Canada.
Sina Rostami - The Influenza Centre, Department of Clinical Science, University of Bergen, N-۵۰۲۱Bergen, Norway
Aida Gholoobi - Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra Meshkat - Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract:

Background: The prevalence of hepatitis C virus (HCV) infection is increasing worldwide. Cytotoxic T-lymphocyte-associated protein ۴ (CTLA-۴) may play a role in the intensity of the disease. The aim of this study was to evaluate the association between genetic variants of the CTLA-۴ and HCV infection. Methods: Restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was performed as the genotyping assay at four different positions (+۴۹ A>G, -۳۱۸ C>T, -۱۷۲۲ T>C, and -۱۶۶۱ A>G). Haplotypes were analyzed using PHASE software. Sixty-five HCV patients and ۶۵ healthy individuals as controls who were referred to the hepatitis clinic in Mashhad, Iran, were recruited. Genomic DNA was extracted from whole blood of participants. Results: In a dominant analysis model of the -۱۶۶۱ position (GG vs. AA+AG), the AA genotype was more common in controls than in patients (adjusted P = ۰.۰۰۰۳; OR = ۰.۱۵, ۹۵% CI = ۰.۰۵۱ -۰.۴۲). The GCAT haplotype was also more prevalent in controls than in patients (adjusted P = ۰.۰۱; OR = ۰.۴۰, ۹۵% CI = ۰.۲۰-۰.۸۱). Furthermore, the ACGT/ACGT diplotype was more common in controls than in patients (P = ۰.۰۰۳۷; OR = ۰.۱۵, ۹۵% CI = ۰.۰۴-۰.۵۴). In addition, the ACGT/ACAT diplotype was more frequent in patients than controls (adjusted P =۰.۰۰۳; OR = ۲.۴۸, ۹۵% CI = ۱.۳۷- ۴.۵۰). Conclusions: Our results indicated that polymorphisms in CTLA-۴ and certain haplotypes may affect the risk of HCV infection in our population, although a larger sample size may be required to confirm this association.

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Sepahi, Samaneh and Pasdar, Alireza and Gerayli, Sina and Rostami, Sina and Gholoobi, Aida and Meshkat, Zahra,1396,CTLA-۴ Gene Haplotypes and the Risk of Chronic Hepatitis C Infection; a Case Control Study,https://civilica.com/doc/1263038

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Paper count: 8,097
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