Histological effects of Carbimazole and eltroxin induced thyroid gland disorders in ovaries of female golden hamster ( Mesocricetus auratus )

Ovaries ,are highly important exocrine and endocrine glands, which lead to the production of ovum and then continuity of species. Hypothyroidism and Hyperthyroidism are represents the most important and leading cause of infertility in females as it was cause ovarian dysfunction. Thirty adult female golden hamster, weighting ۱۶۰-۱۸۰ gm., were included in the study. Animales were divided to three goups: Carbimazole (۱۲ mg /kg body weight ) induced hypothyroidism, eltroxin(۱۰۰ μg /kg body weight) induced hyperthyroidism and control group. Histological results showed that ovaries of hypothyroid hamsters explained an increase in the thickness of tunica albuginea and atretic follicles with dilation in blood vessels ;Whereas ovaries of hyperthyroid hamsters explained degeneration of the primary and secondary ovarian follicles with a vascular congestion. In conclussion hypothyroidism can cause ovarian cysts, follicular atresia , interstitial cells proliferation and delation in the sexual maturation and development;While hyperthyroidism can led to degenerative changes of hamster ovaries , a vascular congestion and a marked decrease in collagen fibers..

Keywords:

thyroid disorders , eltroxin , Carbimazole , Ovary histology , Hamster