Association of urinary triclosan and methyl-triclosan levels with predictive indicators of cardiovascular disease and obesity in children and adolescents in ۲۰۲۰ (case study: Kerman, Iran)
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 245
This Paper With 9 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_EHEM-8-3_004
تاریخ نمایه سازی: 6 مهر 1400
Abstract:
Background: Exposure of children and adolescents to endocrine disrupting chemicals (EDCs) causes the development of non-communicable diseases. Triclosan (TCS) is a fat-soluble antimicrobial agent, and methyl-triclosan (MTCS) is the predominant metabolite of TCS. The increasing use of consumables TCS (toothpaste, mouthwash, personal care products) in human has raised concerns about human health.
Methods: The urinary concentrations of TCS and MTCS were measured by GC/MS. Lipid profiles (TG, TC, LDL, and HDL), anthropometric parameters (WC, BMI z-score, and BMI), FBS, SBP, and DBP tests were performed on ۷۹ children and adolescents.
Results: Of ۷۹ people included as the study population, ۴۲ subjects (۵۳.۱۶%) were males. Most of the study population as ۳۲ subjects (۴۰.۵۰%) were obese. The mean concentrations of TCS and MTCS in the obese population were ۵.۴۷ ± ۲.۹۹ and ۲.۳۲ ± ۱.۰۴ µg/L, respectively. After adjusting for possible confounding factors, the results showed that a one-unit increase in DBP caused a ۰.۰۳ units increase in TCS levels in male subjects (P = ۰.۰۱). A one-unit increase in DBP also caused a ۰.۰۲ units increase in MTCS (P = ۰.۰۰۱). There was a significant relationship between TCS and HDL (OR = ۰.۹۰, P = ۰.۰۰۵), LDL (OR = ۱.۱۳, P = ۰.۰۱), and TG (OR =۱.۰۵, P < ۰.۰۰۰۱). There was also a significant relationship between MTCS and HDL (OR = ۰.۸۸, P = ۰.۰۰۱), LDL (OR = ۱.۰۳, P = ۰.۰۰۹), and TG (OR = ۱.۰۴, P < ۰.۰۰۰۱).
Conclusion: According to the results, there is a relationship between TCS, MTCS, and predictive indicators of cardiovascular diseases and obesity.
Keywords:
Authors
Habibeh Nasab
Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
Moghaddameh Mirzaee
Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
Karim Ebrahimpour
Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
Majid Hashemi
Corresponding author: Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :