Association of urinary triclosan and methyl-triclosan levels with predictive indicators of cardiovascular disease and obesity in children and adolescents in ۲۰۲۰ (case study: Kerman, Iran)

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_EHEM-8-3_004

تاریخ نمایه سازی: 6 مهر 1400

Abstract:

Background: Exposure of children and adolescents to endocrine disrupting chemicals (EDCs) causes the development of non-communicable diseases. Triclosan (TCS) is a fat-soluble antimicrobial agent, and methyl-triclosan (MTCS) is the predominant metabolite of TCS. The increasing use of consumables TCS (toothpaste, mouthwash, personal care products) in human has raised concerns about human health. Methods: The urinary concentrations of TCS and MTCS were measured by GC/MS. Lipid profiles (TG, TC, LDL, and HDL), anthropometric parameters (WC, BMI z-score, and BMI), FBS, SBP, and DBP tests were performed on ۷۹ children and adolescents. Results: Of ۷۹ people included as the study population, ۴۲ subjects (۵۳.۱۶%) were males. Most of the study population as ۳۲ subjects (۴۰.۵۰%) were obese. The mean concentrations of TCS and MTCS in the obese population were ۵.۴۷ ± ۲.۹۹ and ۲.۳۲ ± ۱.۰۴ µg/L, respectively. After adjusting for possible confounding factors, the results showed that a one-unit increase in DBP caused a ۰.۰۳ units increase in TCS levels in male subjects (P = ۰.۰۱). A one-unit increase in DBP also caused a ۰.۰۲ units increase in MTCS (P = ۰.۰۰۱). There was a significant relationship between TCS and HDL (OR = ۰.۹۰, P = ۰.۰۰۵), LDL (OR = ۱.۱۳, P = ۰.۰۱), and TG (OR =۱.۰۵, P < ۰.۰۰۰۱). There was also a significant relationship between MTCS and HDL (OR = ۰.۸۸, P = ۰.۰۰۱), LDL (OR = ۱.۰۳, P = ۰.۰۰۹), and TG (OR = ۱.۰۴, P < ۰.۰۰۰۱). Conclusion: According to the results, there is a relationship between TCS, MTCS, and predictive indicators of cardiovascular diseases and obesity.

Authors

Habibeh Nasab

Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

Moghaddameh Mirzaee

Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Karim Ebrahimpour

Environment Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Majid Hashemi

Corresponding author: Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

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