ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Evaluation of vaccine candidate antigens in Toxoplasma gondii

Year: 1400
COI: MEDISM22_161
Language: EnglishView: 33
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Mohammad Javad Boozhmehrani - Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Elham Rezaee - Gerash University of Medical Sciences, Gerash, Iran

Abstract:

Background and Aim : Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. The parasite has infected almost a third of the world's population, and no suitable vaccine or drug is available. In this study, we examined vaccine candidate antigens in Toxoplasma gondii and reported the best antigens based on scores on the Vaxijen server.Methods : A Vaxquery server was used to find vaccine candidate antigens as well as their protein sequences. Toxicity and allergenicity of these antigens were evaluated with ToxinPred and AllerTOP v.۲.۰ servers, respectively, and finally, their antigenicity for the immune system was measured by the Vaxijen server.Results : A total of ۱۰ proteins GRA۵, hsp۷۰, MIC۱۳, MIC۳, OMPDC, P۳۰, Rop۲, ROP۸, SAG۲, and SOD were examined in this study, ۳ of which (MIC۳, P۳۰, and SAG۲) were identified as allergens, and all except GRA۵ had toxic sequences for humans. GRA۵, MIC۱۳, MIC۳, P۳۰, Rop۲, SAG۲, and SOD antigen scores for the human immune system were more significant than ۰.۵, which is an acceptable score.Conclusion : According to the results, GRA۵ protein with a Vaxijen score of ۱.۰۲۵۴ as the highest score and non-toxicity and non-allergenicity for humans is the best option for predicting epitopes and vaccine design.

Keywords:

Paper COI Code

This Paper COI Code is MEDISM22_161. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1279019/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Boozhmehrani, Mohammad Javad and Rezaee, Elham,1400,Evaluation of vaccine candidate antigens in Toxoplasma gondii,Twenty-second Iranian Congress of Microbiology (Virtual),https://civilica.com/doc/1279019

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 2,943
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support