Prevalence and determination of antibiotic pattern of Enterobacteriaceae causing urinary tract infection in Valiasr Clininc in Mashhad

Background and Aim : Urinary tract infection is one of the most common bacterial infections affecting the human body and the most common type of nosocomial infections. On the other hand, this infection is one of the most common sources of increased antibiotic resistance, which has highlighted the need to evaluate the pattern of antibiotic resistance to improve experimental treatment. The aim of this study was to determine the frequency and pattern of antibiotic resistance of Enterobacteriaceae isolates in patients with urinary tract infections. Methods : In this cross-sectional descriptive study which was performed in the clients of Valiasr Clinic of Mashhad during a quarterly period in ۲۰۲۱, the detection of the desired bacteria was performed using conventional microbiological methods and standard biochemical tests. Disk diffusion method was investigated for determination of antibiotic pattern.Results : Out of ۴۳۸ positive urine cultures for Enterobacteriaceae, Escherichia coli (۷۵.۴%), Klebsiella (۱۴.۶%), Enterobacter (۴%), Proteus (۳.۲%) And other bacterial species were observed in (۲.۸%) cases. Clinical isolates were most sensitive to piperacillin-tazobactam (۸۹%) and amikacin (۸۷%) also had the highest resistance to Cefazolin (۸۱%). Conclusion : Considering the frequency of urinary tract infections and in order to prevent its serious complications, the study of the regional resistance pattern of medical centers for effective treatment should be done in a timely manner. Amikacin and piperacillin-tazobactam antibiotics are recommended for the experimental treatment of urinary tract infections. Finally, more comprehensive clinical statistical research is needed to confirm the findings and results of this clinical study.

Keywords:

Urinary tract infection , Antibiotic pattern , Enterobacteriaceae , Antibiogram