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Paper
Title

Phosphinic amides and oxadiazole ۲-oxides potential drug candidates for schistosomiasis

Year: 1400
COI: MEDISM22_368
Language: EnglishView: 59
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Mohammad Javad Boozhmehrani - Department of Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Elham Rezaee - Gerash University of Medical Sciences, Gerash, Iran

Abstract:

Background and Aim : Schistosomiasis is a chronic parasitic disease that affects the health of millions of people around the world. Due to the increased drug resistance to praziquantel (PZQ), which is the main drug for schistosomiasis, new drugs for the treatment of schistosomiasis are significant. Phosphinic amides and oxadiazole ۲-oxides have been identified as potential anti-schistosomiasis agents that target thiodoxine glutathione reductase (TGR).Methods : For collecting the related published paper, we searched PubMed with the keywords of Schistosomiasis, "Phosphinic amides", and "Oxadiazole ۲-oxides" from ۲۰۰۵ till now.Results : The activities of phosphinic amides and oxadiazole ۲-oxides were examined against both the GR and the TrxR activities of recombinant schistosome TGR. The compounds inhibited both TGR activities, with most showing greater inhibition of the TrxR activity.Conclusion : Given the importance of the TGR system for the survival of Schistosoma in vertebrate hosts, inhibition of this system can limit and inhibit schistosomiasis. Phosphinic amides and oxadiazole ۲-oxides derivatives can well inhibit this system and prevent the survival of Schistosoma and disease. Therefore, these compounds could be potential drug candidates for schistosomiasis and a viable alternative to praziquantel.

Keywords:

Paper COI Code

This Paper COI Code is MEDISM22_368. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1279226/

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Boozhmehrani, Mohammad Javad and Rezaee, Elham,1400,Phosphinic amides and oxadiazole ۲-oxides potential drug candidates for schistosomiasis,Twenty-second Iranian Congress of Microbiology (Virtual),https://civilica.com/doc/1279226

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Type of center: علوم پزشکی
Paper count: 2,938
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