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Chronoefficacy of alpha-lipoic acid in combination with nifedipine and glimepiride attenuates testicular toxicity in diabetic rats

Publish Year: 1400
Type: Journal paper
Language: English
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JR_PJMT-10-3_001

Index date: 3 October 2021

Chronoefficacy of alpha-lipoic acid in combination with nifedipine and glimepiride attenuates testicular toxicity in diabetic rats abstract

Background: Knowledge of chronopharmacology and disease rhythms may provide additional therapeutic options for diabeticcomplications. The present research investigates the effect of chronomodulated alpha-lipoic acid/ nifedipine/ glimepiride combinationin oxidative stress-mediated testicular toxicity in diabetic rats. A total of seven rat groups were used for the following study.Methods: A group of non-diabetic rats and a group of diabetic rats were treated with 1 mL/kg of water to serve as normal and diabeticcontrols respectively. All other groups were diabetic and received 10 mg/kg glimepiride at 20:00h. Additionally, groups four to sevenwere treated with 20 mg/kg nifedipine at 08:00h while groups five to seven received additional treatments with alpha-lipoic acid(ALA) at 08:00h, 14:00h and 20:00h respectively. Rats were euthanized after four weeks of oral treatment and the epididymis andtestis were excised for assessment of fertility markers. Serum testosterone and relative testes weights were measured. The right testeswere preserved in phosphate buffer for cholesterol and antioxidant assay while the left testes were fixed in formalin for histologicalstudies.Results: All rat groups treated with ALA showed significantly (p ≤ 0.01) better prognostic values for all markers assessed comparedto the diabetic control group. Those treated with ALA at 20:00h showed better prognosis (p ≤ 0.05) than treatment at other time points,showing values similar to the normal.Conclusion: Time-dependent triple therapy with alpha-lipoic acid, nifedipine and glimepiride mitigates oxidative stress-mediatedtesticular injury in diabetic rats and its clinical benefits may be explored using equivalent circadian timing in men.

Chronoefficacy of alpha-lipoic acid in combination with nifedipine and glimepiride attenuates testicular toxicity in diabetic rats Keywords:

Chronoefficacy of alpha-lipoic acid in combination with nifedipine and glimepiride attenuates testicular toxicity in diabetic rats authors

Michael Oraebosi

department of pharmacology and therapeutics ABU zaria

Temidayo Olurishe

department of pharmacology and therapeutics ABU zaria

Sherifat Anafi

department of pharmacology and therapeutics ABU zaria

Mohammed Bisalla

Department of Veterinary Pathology and Microbiology, Ahmadu Bello University, Zaria, Nigeria

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ReferencesAkerstedt T, Gillberg T. The Circadian Variation of Experimentally Displaced ...
Hermida RC, Ayala DE, Mojón A, Fernádez JR. Influence of ...
Bolli GB, Gerich JE. The “Dawn-Phenomenon”, a common occurrence in ...
Mangoli E, Talebi AR, Anvari M, Pourentezari M. Effects of ...
Singh S, Malini T, Rengarajan S, Balasubramanian K. Impact of ...
Amaral S, Moreno AJ, Santos MS, Seica R, Ramalho-Santos J. ...
Roessner C, Paasch U, Kratzsch J, Glander HJ, Grunewald S. ...
Baradaran A, Nasri H, Rafieian-Kopaei M. Comment on: antioxidative stress ...
Kawahito S, Kitahata H, Oshita S. Problems associated with glucose ...
Baynes HW. Classification, Pathophysiology, Diagnosis and Management of Diabetes Mellitus. ...
Alhadramy MS. Diabetes and oral therapies: A review of oral ...
Mak IT, Boehme P, Weqlicki WB. Antioxidant effects of calcium ...
Robertson S, Cameron ME, Cotter MA. Effect of calcium antagonist ...
Budin SB, Kee KP, Eng MY, Osman K, Bakar MA, ...
Prathima P, Venkaiah K, Pavani R, Daveedu T, Munikumar M, ...
Oraebosi MI, Olurishe TO, Ayanwuyi LO. Chronomodulated Nifedipine Offers Reno-protection ...
Oraebosi MI, Olurishe TO, Ayanwuyi LO. Chronomodulated Nifedpine Supports Concurrent ...
Hussain HE, Jamil K, and Mala R. Hypoglycemic, hypolipidemic and ...
Belsey MA, Moghissi KS, Eliasson R, Paulsen CA, Gallegos AJ, ...
Talbot P, Chacon. R.S. A triple-stain technique for evaluating normal ...
Linder RE, Strader LF, Slott VL, Suarez JK. Endpoints of ...
Oraebosi MI, Olurishe TO, Anafi SB, Bisalla M. Chronopharmacology of ...
Zlatkis A, Zak B, Boyle AJ, Mich D (۱۹۵۳) A ...
Arthur SJ, and John BA. colour Atlas of Histopathological Staining ...
Sahoo DK, Roy A. Compromised rat testicular antioxidant defence system ...
Ruder EH, Hartman TJ, Blumberg J, Goldman MB. Oxidative stress ...
Khaki A, Khaki AA, Hajhosseini L, Golzer FS, Ainechi N. ...
Arikawe AP, Daramola AO, Odofin AO, Obika LFO. Alloxan-induced and ...
Manoharan S, Kolanjiappan K. Diurnal rhythmicity of thiobarbituric acid reactive ...
Sani M, Sebai H, Ghanem-Boughanmi N, Boughattas NA, Ben-Attia M. ...
Möller U, Larsen JK, Hendl J, Christensen IJ. The cell ...
Gottreich A, Hammel I, Yogev L, Terkel J. Effect of ...
Kalra PS, Fawcett CP, Krulich L, Cann SMM. Effects of ...
Poland V, Bartke A. Influence of endogenous prolactin on the ...
Beach JE, Trey L, Schomberg DW, Evertt JW. Nocturnal and ...
Obaji-Ogar LT, Nsonwa-Anyanwu AC, Odum FA. Oxidative DNA damage and ...
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