In vivo effects of allogeneic mesenchymal stem cells in a rat model of acute ischemic kidney injury

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-21-8_009

تاریخ نمایه سازی: 27 مهر 1400

Abstract:

Objective(s): Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of ۳۵-۶۰% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induced AKI Wistar rats and evaluating their significance in AKI treatment. Material and Methods: Animals underwent surgical procedure and AKI was induced by ۴۰ min bilateral renal pedicle clamping. Immediately after reperfusion, ۲×۱۰۶ rat bone marrow derived MSCs were injected via intra-parenchymal or intra-aortic route. Results: Animals subjected to AKI after days ۱ and ۳ showed significant increase in the serum creatinine and blood urea nitrogen (BUN) concentration along with a declined glomerular filtration rate (GFR) when compared with non-ischemic animals. On the other hand, treated animals showed a significant enhanced regeneration as compared to ischemic animals in both administration route groups. Conclusion: According to the results concluded from the renoprotective effects of MSC in IRI/AKI, MSCs could be considered as promising therapeutic approach for AKI in clinical applications.

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Authors

Shahrzad Havakhah

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mojtaba Sankian

Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Gholam Hosein Kazemzadeh

Department of Vascular Surgery, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

kayvan sadri

Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Hamid Reza Bidkhori

Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran

Hojjat Naderi-Meshkin

Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran

Alireza Ebrahimzadeh Bideskan

Microanatomy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Saeed Niazmand

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ahmad Reza Bahrami

Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad Branch, Mashhad, Iran

Abolfazl khajavirad

Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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