The effect of Quercus brantii gall extract on burn wound healing in rat

Objective(s): The aim of the present study was to evaluate the effect of Quercus brantii galls extract on the rat skin burn wound healing. Materials and Methods: Ethanol extract of the galls of Q. brantii was used to treat the induced burn wounds on the back of ۳۲ Wistar rats divided into ۴ groups. The groups were treated by placebo, ۱%, ۲% and ۴% concentration gall extract gels for ۱۴ days and the efficacy of treatment was assessed based on reduction of burn wound area, as well as histological and molecular characteristics. Results: The mean wound surface in the ۱۴th day, in all groups treated by Q. brantii gall extracts were larger than control group and the differences were statistically significant (P=۰.۰۴۳). The mean histological wound healing scores were not statistically different. Analysis of nitric oxide and platelet derived growth factor concentration in wound fluids in the ۵th day of study showed that there was not any significant difference between groups (P=۰.۴۶۸ and ۰.۳۱۲ respectively). Fibroblast growth factor (bFGF) concentration in the wound fluids, was significantly higher in group treated with ۱% gall extract gel in comparison to the control group (P=۰.۰۲۶). Conclusion: Our results could not prove the significant positive effect of Q. brantii galls extract on the burning wound healing. More studies with more groups treated with different doses of the Q. brantii extract are recommended.

Keywords:

Burn wound healing , Gall extract , Quercus Brantii