Antiviral Activity of Obtained Extracts from Different Parts of Cupressus sempervirens against Herpes Simplex Virus Type ۱

Publish Year: 1388
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-12-3_002

تاریخ نمایه سازی: 30 مهر 1400

Abstract:

Objective(s) The aim of this study was to search for new antiviral agents from herbal medicines. Ethanol extracts of C. semipervirens, C. semipervirens var. horizontalis and C. semipervirens cv. Cereiformis were used in experiments to test their influence on herpes viruses (HSV-۱). Materials and Methods HeLa cells monolayers were infected with herpes viruses (HSV-۱). Antiviral activity of the plant extracts assessed using Hematoxylin & Eosin method and observed under a light microscope. All tests were compared with a positive control, acyclovir. Results Results showed that all three plants have antiviral activity against HSV-۱ virus. The most active extract was the obtained extract from C. semipervirens. Among the different parts of this medicinal plant tested, the fruit’s extract appeared to possess the strongest anti- HSV activity. Conclusion In conclusion, of the extracts tested in this survey all showed significant antiviral potency.

Authors

Seyed Ahmad Emami

Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Tayarani-Najaran

Department of Pharmacology and Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Masoud Sabouri Ghannad

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Pezhman Khajeh Karamadini

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Mehrangiz Khajeh Karamadini

Department of Microbiology, Quaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran

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