Ensete superbum ameliorates renal dysfunction in experimental diabetes mellitus
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 19، Issue: 1
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-19-1_015
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s):Hyperglycemia mediated oxidative stress plays a key role in the pathogenesis of diabetic complications like nephropathy. In the present study, we evaluated the effect of ethanolic extract of Ensete superbum seeds (ESSE) on renal dysfunction and oxidative stress in streptozotocin-induced diabetic rats. Materials and Methods:Glucose, HbA۱c, total protein, albumin, renal function markers (urea, uric acid and creatinine), and lipid peroxidation levels were evaluated. Renal enzymatic and non-enzymatic antioxidants were examined along with renal histopathological study. Results:ESSE (۴۰۰ mg/kg BW t) administration reduced glucose and HbA۱c, and improved serum total protein and albumin in diabetic rats. ESSE in diabetic rats recorded decrement in renal function markers and renal lipid peroxidation products along with significant increment in enzymatic and non-enzymatic antioxidants. Renal morphological abnormalities of diabetic rats were markedly ameliorated by E.superbum. Conclusion:These results suggest that the antioxidant effect of E. superbum could ameliorate oxidative stress and delay/prevent the progress of diabetic nephropathy in diabetes mellitus.
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Authors
MS Sreekutty
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-۶۹۵۵۸۱, Kerala, India
S Mini
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram-۶۹۵۵۸۱, Kerala, India
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