Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 14، Issue: 5
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-14-5_004
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their anti inflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods Anti-inflammatory activity was performed by compound ۴۸/۸۰ induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound ۴۸/۸۰ and sheep serum induced mast cell degranulation methods. Results The ethanol extract (۳۰۰ mg/kg) and petroleum ether extract (۱۰۰ mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (۶۹%) by compound ۴۸/۸۰ model. In sheep serum model the ethanol extracts (۱۵۰ and ۳۰۰ mg/kg) and petroleum ether extract (۱۰۰ mg/kg) showed good mast cell stabilizing activity (۶۶-۶۷%). Ethanol extract at ۱۵۰ mg/kg showed ۷۰% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.
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Authors
Jessy Elizabeth Mathew
Department of Pharmaceutical Chemistry, MCOPS, Manipal University, Karnataka, India
Srinivasan Keloth Kaitheri
Department of Pharmaceutical Chemistry, MCOPS, Manipal University, Karnataka, India
Seekarajapuram DinakaranVachala
Department of Pharmaceutical Chemistry, MCOPS, Manipal University, Karnataka, India
Magi Jose
Department of Pharmaceutical Chemistry, MCOPS, Manipal University, Karnataka, India
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