Safety Assessment of Ocimum Basilicum Hydroalcoholic Extract in Wistar Rats: Acute and Subchronic Toxicity Studies

Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
View: 124

This Paper With 9 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-15-1_006

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s) Ocimum basilicum L. is widely used in folk medicine of many countries including Iran. Both O. basilicum and its oil extract have received considerable attention for their potential medicinal properties, but there are a few reports about possible toxicity of this plant. Therefore, in the present study, acute and subchronic toxicity of O. basilicum hydroalcohlic extract have been evaluated in Wistar rats. Materials and Methods For the acute toxicity assessment, five groups of ۱۰ animals (۵ male, ۵ female) received four different single dose of extract orally, the animals were, then, kept under observation for ۱۴ days. For subchronic toxicity, the animals were divided into four groups (۵ male, ۵ female) and were gavaged daily by ۵۰, ۲۰۰ and ۵۰۰ mg/kg of extract.  Mortality, clinical signs, body weight changes, food and water consumption, and hematological and biochemical parameters were monitored during the study period. On the ۴۵th day, animals were sacrificed and gross findings, weight of liver and left kidney and liver histological markers were assessed. Results The results of acute study indicated that LD۵۰ of O. basilicum is higher than ۵ mg/kg. In subchronic study, no adverse effects were observed on serum parameters in male and female rats. The hematological results showed a reduction in the hematocrit, platelets and RBC in both sexes. No abnormalities were observed in other parameters. Conclusion Based on the results of this study, present data suggest that hematologic system could serve as a target organ in oral toxicity of this plant.

Authors

Hamid Reza Rasekh

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Leila Hosseinzadeh

School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

Soghra Mehri

School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Kamli-Nejad

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Majid Aslani

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Farahnaz Tanbakoosazan

School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Javanmardi J, Khalighi A, Kashi H, Vivanco J M. Chemical ...
  • Zeggwagh NA, Sulpice T, Eddouks M. Anti-hyperglycaemic and hypolipidemic effects ...
  • Akhtar MS, Munir M. Evaluation of the gastric antiulcerugenic effects ...
  • Ilhan K, Nazife Y, Mehlika B. Antimicrobial activity of various ...
  • Dasgupta T, Rao AR, Yadava P K. Chemomodulatory efficacy of ...
  • Stajkovic O, Tanja B, Dragana M, Slavisa S, Branka VG, ...
  • Capecka E, Mareczek A, Leja BM. Antioxidant activity of fresh ...
  • Umar A, Imam G,Yimin W, Kerim P. Anti hypertensive effects ...
  • Chopra R N, Nayar S L, Chopra I C. Glossary ...
  • Fandohan P, Gnonlonfin B, Laleye A. Gbenou J D, Darbou ...
  • Pereira A, Carvalho MC, Lima LM, Caputo LRG, Ferreira LR, ...
  • Rasekh HR, Nazari P, Kamli-Nejad M, Hosseinzadeh L. Acute and ...
  • Curtis D. Klassen.Casarett and Doull’s Toxicology: The basic science of ...
  • Raza M, Al-Shabanah OA, El-Hadiyah TM, Al-Majed AA. Effect of ...
  • Orafidiya LO, Agbani EO, Iwalewa EO, Adelusola KA, Oyedapo OO. ...
  • Paul V, Tan A,Christophe MG, Enow-Orock , Njifutie N, Theophlie ...
  • نمایش کامل مراجع