The effect of silver nanoparticles on apoptosis and dark neuron production in rat hippocampus

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-18-7_003

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s):Silver nanoparticles (Ag-NPs) are used widely in bedding, water purification, tooth paste and toys. These nanoparticles can enter into the body and move into the hippocampus. The aim of this study was to investigate the neurotoxicity of silver nanoparticles in the adult rat hippocampus. Materials and Methods:۱۲ male Wistar rats were randomly divided into two experimental and control groups (۶ rats in each group). Animals in the experimental group received Ag-NPs (۳۰ mg/kg) orally (gavage) for ۲۸ consecutive days. Control group in the same period was treated with distilled water via gavage. At the end of experiment, animals were deeply anesthetized, sacrificed, and their brains were collected from each group. Finally the brain sections were stained using toluidine blue and TUNEL. Then to compare the groups, dark neurons (DNs) and apoptotic neurons were counted by morphometric method. Results: Results showed that the num bers of DNs and apoptotic cells in the CA۱, CA۲, CA۳, and dentate gyrus (DG) of hippocampus significantly increased in the Ag-NPs group in comparison to the control group (P<۰.۰۵). Conclusion: Exposure to Ag-NPs can induce dark neuron and apoptotic cells in the hippocampus.

Authors

Farzaneh Bagheri-abassi

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hassan Alavi

Electronic Microscope Center, Buali Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Abbas Mohammadipour

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Motejaded

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Alireza Ebrahimzadeh-bideskan

Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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