Effect of Erythropoietin on Serum Brain-derived Biomarkers after Carbon Monoxide Poisoning in Rats

Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
View: 165

This Paper With 7 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_IJBMS-15-2_009

تاریخ نمایه سازی: 3 آبان 1400

Abstract:

Objective(s) Erythropoietin has been shown to exert neuroprotective effects in a variety of CNS injury models. Elevation of serum S۱۰۰β, as a glial damage marker and myelin basic protein (MBP) has been reported to occur in acute carbon monoxide (CO) poisoning. The aim of this study was to evaluate the effect of erythropoietin (EPO) on serum S۱۰۰β and MBP levels after CO poisoning in rats. Materials and Methods Rats were poisoned with a mixture of ۳۰۰۰ PPM CO in air for ۶۵ min. After exposure, half of the rats received ۵۰۰۰ u/kg EPO and the rest received normal saline. At ۳, ۶, ۱۲, ۲۴, ۴۸, ۷۲, ۱۴۴, and ۳۳۶ hr after exposure samples were taken. Additionally, EPO was administered at three lower doses (۶۲۵, ۱۲۵۰ and ۲۵۰۰ u/kg). The serum S۱۰۰β and MBP levels were measured using immunoenzymatic colorimetric assay. Hemoglobin level was alsomeasured. Results Serum S۱۰۰β levels in CO poisoned rats were significantly higher compared to the control group [۶ hr (P< ۰.۰۱), ۱۲ hr (P< ۰. ۰۰۱), ۲۴ hr (P< ۰.۰۰۱), ۴۸ hr (P< ۰.۰۰۸) and ۷۲ hr (P< ۰.۰۰۸)]. EPO administration could significantly prevent serum S۱۰۰β elevations after ۱۲ hr (P< ۰.۰۰۸) and ۲۴ hr (P< ۰.۰۰۸) of CO poisoning. Serum MBP levels in CO poisoned rats were not significantly increased in comparison with the control group (P> ۰.۰۵). EPO significantly increased the hemoglobin levels. Conclusion EPO could partially prevent neuronal damage. More studies are required to elucidate other aspects of these effects.

Authors

Shabnam Shahsavand

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Amir Hooshang Mohammadpour

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Ramin Rezaee

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Effat Behravan

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Ramin Sakhtianchi

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Adel Moallem

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Omaye ST. Metabolic modulation of carbon monoxide toxicity. Toxicology. ۲۰۰۲; ...
  • Marenholz I, Heizmann CW, Fritz G. S۱۰۰ proteins in mouse ...
  • Schiltz KL. Failure to assess motivation, need to consider psychiatric ...
  • Bell MJ, Kochanek PM, Heyes MP, Wisniewski SR, Sinz EH, ...
  • Hans P, Born JD, Chapelle JP, Milbouw G. Creatine kinase ...
  • Brvar M, Mozina H, Osredkar J, Mozina M, Brucan A, ...
  • Brvar MMD, Finderle aMDP, Suput DMDP, Bunc MMDP. S۱۰۰B protein ...
  • Vos PE, Lamers KJB, Hendriks JCM, Van Haaren M, Beems ...
  • Yardan T, Cevik Y, Donderici O, Kavalci C, Yilmaz FM, ...
  • Nylén K, Öst M, Csajbok LZ, Nilsson I, Hall C, ...
  • Hergenroeder GW, Redell JB, Moore AN, Dash PK. Biomarkers in ...
  • Thom SR,Bhopale VM,Fisher D.Hyperbaric oxygen reduces delayed immune-mediated neuropathology in ...
  • Ide T, Kamijo Y. Myelin basic protein in cerebrospinal fluid: ...
  • Hu M-C, Shiah IS, Yeh C-B, Chen H-K, Chen C-K. ...
  • Agnello D, Bigini P, Villa P, Mennini T, Cerami A, ...
  • Sattler MB, Merkler D, Maier K, Stadelmann C, Ehrenreich H, ...
  • Bloomfield S, McKinney J, Smith L, Brisman J. Reliability of ...
  • Gunnarson E, Song Y, Kowalewski JM, Brismar H, Brines M, ...
  • Petzold A, Eikelenboom MJ, Gveric D, Keir G, Chapman M, ...
  • Schofield P. Dementia associated with toxic causes and autoimmune disease. ...
  • Juul S. Erythropoietin in the central nervous system, and its ...
  • Li Y, Hu X, Lu Z. Erythropoietin in the treatment ...
  • نمایش کامل مراجع