Nephroprotective potential of Graptophyllum pictum against renal injury induced by gentamicin

Objective(s):To evaluate the effect of Graptophyllum pictum on lipid peroxidation and tissue antioxidant enzymes in liver and kidney of gentamicin induced nephrotoxic rats. Materials and Methods: Animals were grouped into ۶: Group ۱ received gum acacia, Group ۲ received G. pictum ethanol extract (۳۰۰ mg/kg), Group ۳ received gentamicin, Groups ۴, ۵, ۶ received gentamicin along with G. pictum at ۳۰۰, ۱۵۰, ۷۵ mg/kg, respectively. Nephroprotective activity was evaluated by measuring thiobarbituric acid-reactive substances (TBARS), biochemical markers  Glutathione (GSH), Glutathione-S Transferase(GST), Superoxide dismutase (SOD), Catalase (CAT), serum urea and creatinine levels. Results: Results obtained showed that gentamicin induced nephrotoxic rats exhibited lower activities of biochemical markers and raised levels of TBARS, serum creatinine and urea. Remarkably, after treatment with G. pictum extract, anomalous levels of biochemical markers, lipid peroxidation and serum creatinine were returned to normal. Conclusion: The results propose that G. pictum has nephroprotective effects, and can be a promising natural source against gentamicin induced nephrotoxicity.

Keywords:

Graptophyllum pictum , Gentamicin , Glutathione , Nephrotoxicity , Oxidative stress