Effect of Vitamin Supplementation on Serum Oxidized Low-Density Lipoprotein Levels in Male Subjects with Cardiovascular Disease Risk Factors
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 15، Issue: 4
Publish Year: 1391
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-15-4_009
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s) Oxidized low-density lipoproteins (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors. Materials and Methods The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after ۱۲ weeks of supplementation with vitamin E (۴۰۰ IU), C (۵۰۰ mg), ß-carotene (۱۵ mg), and the combined supplements (E, C, and ß-carotene) respectively defined as group E, C, B and control group was considered as group P. Results The mean values for ox-LDL at the baseline were ۸۶.۹۳ ± ۲۶.۳۰ U/l in group C, ۹۴.۵۲ ± ۳۸.۴۰ U/l in group E, ۷۹.۷۳±۲.۰۷ U/l in group B, ۸۵.۹۷±۲۳.۰۷ U/l in combined group, and ۸۴.۹۰± ۱۴.۶۶ U/l in group P. After ۱۲ weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-۱۸.۳۲), (-۲۲۸۶), (-۱۷.۳۱), (-۱۹.۰۱) and (-۲.۰), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P< ۰۰۵). Conclusion This study illustrated that diet supplemented with vitamin C (۵۰۰ mg), vitamin E (۴۰۰ IU), ß-carotene (۱۵ mg), and the combination of these vitamins was associated with lower serum ox-LDL levels.
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Authors
Saeid Najafpour Boushehri
Faculty of Health, Bushehr University of Medical Sciences. Bushehr, Iran
Rokiah Mohammad Yusof
Department of Nutrition and Dietetics. Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia
Mohammad Nasir Mohammad Taib
Department of Nutrition and Dietetics. Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia
Kamran Mirzaei
Faculty of Health, Bushehr University of Medical Sciences. Bushehr, Iran
Narges Yazdekhasti
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences. Isfahan, Iran
Samad Akbarzadeh
Faculty of Health, Bushehr University of Medical Sciences. Bushehr, Iran
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