Crocin Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 16، Issue: 1
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-16-1_009
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into ۹ groups: groups ۱-۴ (intact + normal saline and intact + crocin at doses of ۵, ۲۰ and ۸۰ mg/kg, respectively); group ۵ (sham surgery + normal saline); groups ۶-۹ (crush + normal saline and crush + crocin at doses of ۵, ۲۰ and ۸۰ mg/kg, respectively). Normal saline and crocin were IP injected for ۱۰ consecutive days after induction of a standard crush injury in left sciatic nerve. Footprints were obtained ۱ day before and weekly after induction of nerve injury for evaluation of sciatic functional index (SFI). Blood samples were taken for evaluation of malondialdehyde (MDA) levels. Histopathological changes of sciatic nerve were investigated by light microscopy. Results: Sciatic nerve crush-injured rats showed SFI values reduction, increased plasma MDA levels and produced Wallerian degeneration in sciatic nerve. Crocin at a dose of ۵ mg/kg had no significant effects. At doses of ۲۰ and ۸۰ mg/kg, crocin accelerated the SFI recovery, decreased MDA levels and reduced Wallerian degeneration severity. Conclusion: The present study suggests that the neuroprotective effects afforded by crocin may be due in part to reduction of free radicals-induced toxic effects.
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Authors
Esmaeal Tamaddonfard
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Amir Abbas Farshid
Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Elham Ahmadian
Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Abbas Hamidhoseyni
Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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