Ghrelin Does not Alter Aortic Intima-Media Thickness and Adipose Tissue Characteristics in Control and Obese Mice

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-16-8_010

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s): Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. Materials and Methods:This study was conducted on ۲۴ male C۵۷BL/۶ mice. The animals were divided into four groups: control, obese (received high fat diet), control+ghrelin (injected with ۱۰۰ µg/Kg subcutaneously, bid) and obese+ghrelin (n=۶ each). After ۱۰ days, animals were sacrificed and epididymal adipose tissue and thoracic aortae were removed. Adipocyte cell number, size and aortic intima-media thickness were evaluated. Results:Ghrelin did not change adipocyte cell number and size and aortic intima-media thickness in obese and control mice. In this study, high fat diet significantly decreased the number of adipocyte cells while increased their size (P<۰.۰۵). Ghrelin administration had no significant effect on adipocyte cell number and size in obese and control groups (P >۰.۰۵). In addition, it could not alter aortic intima-media thickness in both groups. Conclusion: Although ghrelin has several cardiovascular effects, it seems that it could not alter the size and number of adipocyte cells and aortic intima-media thickness in diet-induced obese mice

Keywords:

Adipocyte Atherosclerosis Ghrelin Obesity

Authors

Zoya Tahergorabi

Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

Bahman Rashidi

Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran

Majid Khazaei

Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

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