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The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice

Publish Year: 1393
Type: Journal paper
Language: English
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JR_IJBMS-17-4_001

Index date: 26 October 2021

The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice abstract

Objective(s): The goal of this study was assessing the prophylactic effect of exercise and its role as an adjuvant therapy on level of cytokines involved in angiogenesis in estrogen-dependent breast cancer. Materials and Methods: Forty female BALB/c mice were randomly assigned to exercise-tumor-exercise (ETE), exercise-tumor-rest (ETR), rest-tumor-exercise (RTE) and rest-tumor-rest (RTR) groups. After orientation in the environment, two groups of mice performed continuous endurance exercise for 8 weeks, and thereafter estrogen-dependent MC4L2 cancer cells were injected to them. Then, one group of each of trained and non-trained mice performed endurance exercise 5 days per week for 6 weeks. Tumor volume was measured by a digital caliper weekly. Finally, the mice were sacrificed; tumor tissue was removed, immediately frozen and kept in              -70°C. Tumor sample was homogenized; levels of cytokines were measured and quantified using ELISA. Results: There was significant reduction in the level of interlukin-6 (IL-6) (P=0.001), Vascular endothelial growth factor (VEGF) (P=0.0001) and tumor volume (P=0.0001) among the groups performing endurance exercise after malignancy (RTE and ETE) in comparison with groups not performing endurance exercise (ETR and RTR), and these results were in agreement with tumor growth rate. Conclusion: Exercise can cause reduction in levels of pro-inflammatory cytokines in tumor tissue. Decreased IL-6 production could reduce the generation of VEGF, resulting in reduced intra-tumor angiogenesis. Due to reduction of the level of these cytokines in groups doing exercise before and after malignancy, exercise is presumed to be an adjuvant therapy in estrogen-receptor dependent tumors in addition to its effective prophylactic role.

The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice Keywords:

Endurance training , Estrogen receptor depen-dent cancer , IL-6 , VEGF

The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice authors

Sadegh Amani Shalamzari

Physical Education Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

Hamid Agha-Alinejad

Physical Education Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

Shaban Alizadeh

Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran

Shirin Shahbazi

Medical Genetics Department, Faculty of Medical Sciences, ,Tarbiat Modares University, Tehran, Iran

Zahra Kashani Khatib

Medical Genetics Department, Faculty of Medical Sciences, ,Tarbiat Modares University, Tehran, Iran

AbdolReza Kazemi

Physical Education Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

Mohamad Amin Saei

Physical Education Department, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran

Neda Minayi

Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran

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