Niosomal Gels for Use in Skin Treatments

Human skin protects the body as a barrier against external attacks by microorganisms and other environmental factors. Drug release through the skin does not pose the risks of oral and injectable drug delivery, and the drug does not pass through paths with different pH, so there are no problems in the breakdown and metabolism of the drug in the body, and there is targeted delivery of the drug. There are different carriers for this type of release. However, today niosomes have received much attention because of their many benefits, including biodegradability, biocompatibility, and the ability to encapsulate large amounts of drug material in small volumes of vesicles, greater patient satisfaction, and greater effectiveness. Nevertheless, the physical stability of niosomes is a significant obstacle that limits their application to drug delivery systems. In order to reduce the rapid leakage of encapsulated drugs from the niosomes or minimize the explosive release observed in them, the niosomes are placed in a bed. Gels are suitable substrates for niosomes to improve release; therefore, this article reviews the reports of preparation and evaluation methods of gels containing niosome, and comparing gels containing niosome with gels without niosome. The results showed that higher viscosity, better penetration, more skin retention, and slower release were the characteristics of niosome-containing gels compared to niosome-free gels.

Keywords:

Skin , Niosome , Gel.