Medical and Pharmacological Study of Sinus Approach for Cushing's Disease in Iranian Hospitals (Case Study: ۸۴ Patients with Cushing Disease)

The main aim of this study was to find out some new findings about Sinus Approach for Cushing's Disease in Iranian Hospitals with t-test in this way. Although pituitary adenoma (PA) is one of the three most common brain tumors besides glioma and meningioma. Its prevalence is even higher in autopsy series and screening radiologic studies in the normal population. PAs can be either functional (tumor secreting) or nonfunctional. Proportion of different kinds of PAs is reported differently in studies. Up to half of all PAs may be nonfunctional (including FSH/LH secreting tumors). In this research study, we have assessed ۸۴ patients with Cushing disease, retrospectively. The mean age was ۴۹.۴ years. There were ۴۹ female ۳۵ male patients. They are classified as usual cases of macroadenomas and microadenomas and a third group of intricate Cushing’s disease (ICD). ICD comprises reoperation cases, MRI- negative patients, and cases with multiple microadenomas.  All patients have undergone trans-sphenoid endoscopic surgery. ICD patients are operated either by conventional transsphenoidal endoscopic surgery or by TPTICS modification.  Demographic information and postsurgical outcome are compared among these groups. An informed consent was filled and signed by all patients. Statistical analysis was performed using SPSS ۲۰. P values lower than ۰.۰۵ are considered to be significant. Chi Square and student t tests were used to compare nominal and continuous variables, respectively, between study groups.

Keywords:

Cushing Disease , Endoscopic Trans-Sphenoid , Pituitary adenoma , Trans-Planum , Trans-Inter-Cavernous