Evaluating the Effect of Supernatant Collected from the Culture of Bifidobacterium bifidum on the Increase of Angiogenesis in Acute Wound Healing
Publish place: Iranian Journal of Medical Microbiology، Vol: 15، Issue: 5
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJMM-15-5_004
تاریخ نمایه سازی: 20 آذر 1400
Abstract:
Background and Objective: Wound healing is the result of interactions between cytokines, growth factors, blood, and extracellular matrix. Facing this challenging issue has become one of the essential concerns in health and medical fields, needing different remedies. One of the newest treatments in wound healing is the application of probiotic bacteria. Therefore, the aim of the current study is to evaluate the effect of Bifidobacterium bifidum probiotic bacteria on acute wound healing and exploring the potential of their supernatant on increasing angiogenesis in female mice in the form of biological dressing.
Materials and Methods: ۴۴ female BALB/c mice were studied into six groups in two phases of ۷ and ۱۴ days. After the wounding process, wound sizes were measured by a digital caliper every ۴۸ hours. Mice were dressed and treated. Histological samples were studied, and the results were analyzed statistically.
Results: Bifidobacterium bifidum probiotic bacteria not only show exciting potential as a therapeutic and effective agent but also our examination proved that application of this probiotic plus Aloe vera hydrogel (experimental group ۱) can significantly reduce the wound healing duration and increases angiogenesis (P<۰.۰۵).
Conclusion: According to the findings of this study, the designed biological dressing, including Bifidobacterium bifidum supernatant and Aloe vera hydrogel, can be used in acute wound healing after further studies.
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Authors
Pegah Moussavi amin
Department of Biology, East Tehran Branch, Islamic Azad University, Tehran, Iran
Akram Sadat Tabatabaee Bafroee
Department of Biology, East Tehran Branch, Islamic Azad University, Tehran, Iran
Babak Khalili Hadad
Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Roudehen Branch, Tehran, Iran
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