The effect of thymol on serum levels of total antioxidants (TAC) and tumor necrosis factor (TNF-α) in obese mice

Obesity is the result of an unhealthy diet, a lack of antioxidants and unsaturated fats. Oxidative stress has a role in the onset of chronic diseases associated with obesity. Thymol is one of the phenolic compounds of thyme which is widely used as a general antiseptic in surgery, agriculture, cosmetics and nutrition industries. In a recent study, the effect of thymol on serum levels of total antioxidant (TAC) and tumor necrosis factor (TNF-α) in obese mice was investigated. The control and experimental groups were fed a standard and high-calorie diet for ۸ weeks, respectively. The experimental group was gavaged with thymol (۱۲ mg / kg / day) for ۸ weeks. The end of treatment, blood samples, to investigate serum TAC and TNF-α was performed. Treatment of obese mice with thymol resulted in a significant increase in serum TAC levels and also a significant decrease in serum TNF-α levels compared to control mice. Because oxidative stress plays a pivotal role in the onset of chronic obesity-related diseases, thymol can be used to treat obesity and increase antioxidant levels.

Keywords:

Thymol , Total Antioxidant , Factor Tumor Necrosis , Obese Mice