computational molecular docking simulation study of Kojic acid glucoside as antibacterial agents
Publish place: 3rd International Congress and 4th National Conference on Biotechnology of Medicinal Plants and Mountain Fungi (Virtual)
Publish Year: 1400
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
BMPM04_142
تاریخ نمایه سازی: 22 آذر 1400
Abstract:
Background & Objective: Kojic acid is a fungal metabolic product produced by a few species of Aspergillus, especially by A. oryzae, which has the Japanese common name koji. This compound is an inhibitor of growth of bacteria and multiplication of viruses. In this study, kojic acid derivative, Kojic acid glucoside, was evaluated as DNA gyrase activity inhibitors. DNA gyrase has long been known as an attractive target for antibacterial drugs.Material & Methods:In order to investigate the mode of interaction of the compound with DNA gyrase active site, the chemical structures of kojic acid glucoside wase designed using ChemDraw program, then transferred into Hyperchem software for energy minimization. Docking study was performed by AutoDock ۴.۲ program and the resulting docking poses were analyzed in AutoDockTools, DS Visualizer ۳.۵ and Ligplot software.Results: Binding model and the best docked pose of this compound showed Kojic acid glucoside formed a hydrogen bond with Asp۷۳,Asn۴۶, Glu۵۰, Thr۱۶۵, Val۷۱,Arg۱۳۶ of DNA gyrase in active site.Conclusion: The in silico molecular docking study results showed that, Kojic acid glucoside have minimum binding energy and good affinity toward the active pocket, thus, this may be considered as good inhibitor of DNA gyrase .
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Authors
Omid Ali Behzadi,
Department of Biology, Faculty of Basic Sciences, Nourdanesh Institute of Higher Education, Meymeh, Isfahan, Iran
Azizeh Asadzadeh
Department of Biology, Faculty of Basic Sciences, Nourdanesh Institute of Higher Education, Meymeh, Isfahan, Iran