Investigation of the Relationship between Serum Leptin levels and Nausea and Vomiting of Pregnancy

Background: Worldwide, half of women suffer from nausea and vomiting in early pregnancy which generally continues to the ۲۰th week of pregnancy. Although pathogeneses of nausea and vomiting of pregnancy as well as hyperemesis gravid arum are still unknown, some believe that  nausea and vomiting of pregnancy is likely related to maternal serum leptin level. Objectives: This study aimed to examine the relationship between leptin and pregnancy nausea and vomiting. Methods: In this case-control study, ۴۵ pregnant women at first and second trimesters were selected through convenient sampling. Mothers’ blood samples were taken in the ۶th, ۱۲th, ۱۵th, and ۲۰th weeks of pregnancy. The participants were devised into healthy, without nausea, (۲۴) and with nausea and vomiting groups (۲۱). The relationship among the variables was analyzed using independent t-test, Pearson correlation, regression tests, and Lambda statistic (P value <۰.۰۵). Results: The mean age of the participants was ۲۷.۴۷±۵.۵۵ years, and Body Mass Index (BMI) was found to be ۵.۴۵۸±۲۶.۵۷. There was no significant difference between groups in this regard. Based on results, changes in maternal serum leptin had significant correlation with nausea and vomiting of pregnancy (p<۰.۰۴), meaning that the mean of leptin changes in patients with nausea and vomiting was significantly lower. Moreover, serum leptin at first and second trimesters of pregnancy did not have significant correlation with nausea and vomiting (p=۰.۵ and ۰.۳, respectively). Conclusion: With regard to leptin peak level at second trimester of pregnancy, leptin changes at first and second trimesters can be a good index to predict the nausea and vomiting of pregnancy. Thus, further domestic studies are required in this respect.  

Keywords:

leptin , pregnancy , nausea , vomiting