Gastroprotective effect of Berberis vulgaris on ethanol-induced gastric mucosal injury: Histopathological evaluations

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JR_AJP-12-1_004

تاریخ نمایه سازی: 27 آذر 1400

Abstract:

Objective: Modern treatment of peptic ulcers includes antibacterial and gastroprotective medications. However, current anti-ulcer drugs possess severe side effects. Therefore, all attempts to find new effective medications free from side effects are justified. Though Berberis vulgaris is a medicinal plant commonly used for the treatment of numerous disorders, gastroprotective effect of its leaf extract was not investigated before.Materials and Methods: Gastric ulcer was modelled in Sprague-Dawley rats after treatment with B. vulgaris leaf extract containing ۰.۰۷% of alkaloids, ۰.۴۸% of flavonoids and ۸.۰۵% of tanning substances, ۱۰ or ۵۰ mg of dry extract/kg, changes in the stomach mucosa were assessed semi-quantitatively, and the gastric wall was evaluated for prostaglandin E۲ level using ELISA and assessed histologically by calculation of the lesion index.Results: B. vulgaris leaf extract at the dose of ۵۰ mg/kg reduced the macroscopic ulcer score and the microscopic lesion index, increased prostaglandin E۲ concentration in the gastric wall significantly higher than atropine and B. vulgaris leaf extract ۱۰ mg/kg.Conclusion: The gastroprotective effect of the high dose of B. vulgaris leaf extract may be due to stimulation of prostaglandin E۲ secretion in the stomach, and anti-oxidative and anti-inflammatory properties of polyphenolic complex of flavonoids and tannins present in the leaves of this plant.

Authors

Marina Kapitonova

Faculty of Medicine and Health Sciences, UNIMAS, Kota Samarahan, Sarawak, Malaysia

Sergey Gupalo

Faculty of Medicine MAHSA University, Bandar Saujana Putra, Jenjarom, Selangor, Malaysia

Renad Alyautdin

Medicinal Products Safety, Scientific Centre for Expert Evaluation of Medicinal Products, Moscow, Russia. Department of Pharmacology, Sechenov University, Moscow, Russia

Ibrahim Ibrahim

Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

Norita Salim

Institute of Medical Molecular Biotechnology, and Faculty of Medicine, UiTM, Sungai Buloh, Selangor, Malaysia

Azhar Ahmad

Institute of Medical Molecular Biotechnology, and Faculty of Medicine, UiTM, Sungai Buloh, Selangor, Malaysia

Saiful Talip

Faculty of Medicine and Health Sciences, UNIMAS, Kota Samarahan, Sarawak, Malaysia

Tin Nwe

Faculty of Medicine and Health Sciences, UNIMAS, Kota Samarahan, Sarawak, Malaysia

Svetlana Morokhina

Department of Pharmacognosy, Sechenov University, Moscow, Russia