C۳۹۵۳T genetic variation in interleukin ۱β and idiopathic male infertility: a systematic review and meta-analysis

According to the World Health Organization, infertility means that a couple will not have children after ۱۲ months of unprotected sex. Half of all cases of infertility are due to male factors. Environmental and genetic factors play a role in idiopathic infertility in men. Genetic polymorphisms in cytokine family genes may be an important risk factor for male infertility. This study aimed to investigate the association of C۳۹۵۳T polymorphism in the interleukin-۱-beta gene with male infertility through a meta-analysis approach. For this study, an electronic search was conducted in reputable databases such as PubMed, Google Scholar, and Science Direct. Finally, three eligible studies were included in our meta-analysis. The results of the meta-analysis showed that C۳۹۵۳T polymorphism was associated with male infertility in allelic model (OR= ۱.۲۱۴۳, ۹۵% CI= ۱.۰۰۵۷; ۱.۴۶۶۲, p= ۰.۰۴۳۳) and homozygous codominant model (OR= ۳.۰۲۹۲, ۹۵% CI= ۱.۵۶۸۱; ۵.۸۵۱۹, p= ۰.۰۰۰۹۷). Another study also showed that there was no publication bias in our study and a sensitivity analysis showed that the exclusion of one study could not have a significant effect on the pooled ORs. Based on these results, the C۳۹۵۳T polymorphism may be a genetic risk factor for idiopathic infertility in men. However, due to the limited number of studies in this meta-analysis, further studies with higher sample sizes and different races are needed to obtain more accurate results.

Keywords:

Male infertility , Interleukin ۱β , C۳۹۵۳T polymorphism , Meta-analysis