Synthesis, Characterization and Biological Activity Study of some New Metal Ions Complexes with Schiff’s Bases Derived from Isatin With [۲-Aminobenzohydrazide

This study discusses the preparation of new series of tetra-dentate complexes Cu (II), Ni (II), Co (II), Zn (II), and Cr (III) complexes with Schiff base (ligand tetradentate) derived from isatin with ۲-aminobenzohydrazide, characterized by IR spectroscopy, mass spectra, UV-Vis, ۱H-NMR and elemental microanalysis. The complexes Cu (II), Ni (II), Co (II), Zn (II), and Cr (III) were characterized using IR spectroscopy, UVVis, magnetic susceptibility, conductive, elemental microanalysis and metal analysis by atomic absorption. The proposed structures of complexes from the all measurements showed that Ni (II), Co (II), Zn (II), and Cr (III) have octahedral shape and Cu (II) has square planer shape. Bioactivity of the Schiff base and complexes were assessed examined with antibacterial activity. Studies were conducted to assess the growth-inhibiting potential of the complexes synthesized, and the ligands, against various bacterial strains.

Keywords:

Isatin , ۲-aminobenzohydrazide , Tetradentate Schiff base complexes