Comparative study on the effect of transition metal (Zn۲+) and alkaline earth metal (Mg۲+) ions on adsorption-release of diclofenac and ibuprofen on nano M-Al-LDH as drug carriers

In this project, three nanoscale M-Al LDHs, which M is a divalent metal (Mg۲+, Zn۲+ and/or a mixture of them and LDH = Layered Double Hydroxide) were synthesized by co-precipitation and characterized by general techniques, such as FTIR, XRD, FESEM, and EDS. LDHs have got different physical properties, such as; crystal size, lattice parameters, morphology and drug delivery. These M-Al LDHs were used as drug carriers for diclofenac and ibuprofen, which adsorption and release percentages of drugs by them were studied and compared. The results showed that Al-LDHs including transition metal (Zn۲+) are suitable for drug delivery purposes. As the mixed divalent (Zn/Mg)-Al LDHs are more efficient drug carriers for both diclofenac and ibuprofen drugs.

Keywords:

nanomaterial , Drug Delivery , Diclofenac , Layered double hydroxides , Transition Metal