A Review on the Applications of Listex™ P۱۰۰ Bacteriophage

Listeria monocytogenes is a Gram-positive, small rod-shaped bacterium that causes listeriosis in animals and humans from eating contaminated food. It can mostly affect susceptible individuals with defective immune systems. Also, the mortality rates, as a result of listeriosis, can be varied between ۳۰ to ۷۵%. Listeria had been reported to be more allergic to antibiotics than Gram-positive bacteria. However, according to reports, Listeria has recently been allergic to the resistance to these antibiotics. Such an increase in antibiotic resistance in Listeria is in line with the worldwide pattern of the increasing prevalence of antibiotic resistance, including multiple antibiotic resistance in many bacterial groups.Therefore, one of the ways to reduce the incidence of this disease in animals and humans is the biological control of this bacterium by bacteriophage. Bacteriophages have been shown to be effective in controlling L. monocytogenes in food. In ۲۰۰۶, the US Food and Drug Administration approved the preparation of two bacteriophages (Listex™ P۱۰۰ and LMP-۱۰۲) for use in certain foods to control L. monocytogenes. The prevalence of foodborne pathogens is the use of phages as biocontrol agents in food. Also, the activation of Phage Listex™ P۱۰۰ against multiple L. monocytogenes serovars allows it to kill L. monocytogenes and its immunogenicity in food and clinical products. The prevalence of foodborne pathogens is the use of phages as biocontrol agents in food. Also, the activation of Phage Listex™ P۱۰۰ against multiple L. monocytogenes serovars allows it to kill L. monocytogenes and its immunogenicity in food and clinical products. 

Keywords:

Listeria monocytogenes , Bacteriophage , Listex™ P۱۰۰ , Bacteriophage Safety