SPR biosensor for uric acid detection

In this paper, we study an SPR biochemical sensor for uric acid detection. The prism-based Kretschmann configuration is implemented for this purpose in which the Al/Al۲O۳/MoS۲/Graphene are coated on the prism, respectively. The transfer matrix method is implemented to achieve the reflection spectra for the proposed sensor at λ=۶۳۳ nm. The Al layer thickness (with ۳nm Al۲O۳ on its surface) has been optimized to obtain the minimum reflection. Also, the effect of single-, bi-, and tri-layers MoS۲ and Graphene are investigated from the sensitivity characteristic point of view. The results show that the proposed sensor has linear operation for biosensing detection with amplitude and angular sensitivity of ۳۶.۸ RIU-۱ and ۹۸.۳۳ deg. RIU-۱, respectively in a detection range of ۱.۳۳۵-۱.۳۴۷ RIU.

Keywords:

Biosensor , ۱D multilayer , SPR , Kretschmann configuration.