Avascular Necrosis of the Femoral Head: Are Any Genes Involved?
Publish place: The Archives of Bone and Joint Surgery، Vol: 3، Issue: 3
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 11 بهمن 1400
Abstract:
Avascular necrosis of the femoral head (ANFH) is a pathologic process that results from interruption of blood supply to the femur bone resulting in the death of bone cells and collapse of the femoral head. Nontraumatic ANFH continuesto be a significant challenge to orthopedic surgeons. While the exact mechanisms remain elusive, many new insights have emerged from research in the last decade that has given us a clearer picture of the pathogenesis of nontraumatic ANFH. Progression to the end stage of ANFH appears to be related to five main mechanisms: hypercoagulable conditions, angiogenesis suppressions, hyperadipogenesis, heritable states, and switching the bone remodelling into bone resorption. Researchers have been examining the pathogenic mechanisms of ANFH but none of these theories have been firmly confirmed although some appear more plausible than the others. All of these factors can switch bone remodelling into bone resorption, which can further lead to ANFH progression ending up to femoral head collapse.
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Authors
Farzaneh Pouya
Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Genetics, Faculty of Medicine
Mohammad Amin Kerachian
Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Genetics, Faculty of Medicine
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