Interleukin-۸-۲۵۱ A/T and CXCR۲ +۱۲۰۸ C/T Genes Polymorphisms in Chronic Rhinosinusitis
Publish place: Iranian Journal of Otorhinolaryngology، Vol: 23، Issue: 1
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJOTO-23-1_004
تاریخ نمایه سازی: 11 بهمن 1400
Abstract:
Introduction: IL-۸ is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-۸ is partially determined by IL-۸-۲۵۱ A/T polymorphism. Hence, the aim of the present study was to investigate the association between IL-۸-۲۵۱ A/T and CXCR۲ +۱۲۰۸ C/T genes polymorphisms and susceptibility to CRS and NP. Materials and Methods: Two hundred and forty fiveCRS patients and ۲۰۴ healthy controls were included in this study. CRS patients were categorized by the existence or absence of NP. IL-۸ promoter-۲۵۱ A/T and CXCR۲ +۱۲۰۸ C/T gene polymorphisms were genotyped via the allele specific PCR (AS-PCR) method. Results: While no remarkable difference was demonstrated between patients and controls for both CXCR۲ +۱۲۰۸ C/T and IL-۸ -۲۵۱ A/T polymorphisms, a significant increase in IL-۸-۲۵۱ AA genotype was detected in CRS patients with NP compared to those without it (۲۹.۳% and ۱۶.۲%, respectively; P=۰.۰۳). Interestingly, this association got far stronger when only non-asthmatic CRS patients were taken into consideration (P=۰.۰۰۱). Conclusion: The results of the present study indicate that the inheritance of IL-۸-۲۵۱ Aallele is associated significantly with NP development in CRS patients. Therefore, NP formation might be a result of the exposure to an intense inflammatory environment, which is more likely in genetically susceptible CRS patients.
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Authors
Bijan Khademi
Department of otorhinolaryngology, Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz,Iran
Seyed Hossein Dastgheib
Department of otorhinolaryngology, Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
Eskandar Kamali-Sarvestani
Department of immunology, Shiraz University of Medical Sciences, Shiraz, Iran