Kindlin۱ As a Sex and Location Specific Diagnostic Marker in Gastric Cancer Patients

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJP-17-1_004

تاریخ نمایه سازی: 14 بهمن 1400

Abstract:

Background & Objective: Gastric cancer (GC) is considered one of the main reasons for cancer-related mortalities among Iranians. Kindlin-۱ is an adhesion protein member of integrin-interacting proteins, regulating integrin activation through direct interaction with β-integrin. Therefore, kindlin-۱ can be involved in the regulation of cell proliferation and adhesion. In the present study, we assessed the possible role of kindlin-۱ in GC progression and metastasis.Methods:  KINDLIN۱ messenger RNA (mRNA) expression was assessed in tumor tissues from ۸۰ GC patients in comparison with normal tissues using real-time polymerase chain reaction (PCR).Results: The levels of KINDLIN۱ expressions were significantly correlated with sex (P=۰.۰۵) and tumor location (P=۰.۰۰۲). KINDLIN۱ expression was also significantly associated with lymph node metastasis among the helicobacter pylori (HP)-negative cases (P=۰.۰۰۱). Moreover, a significant association between age and KINDLIN۱ expression was observed among the HP-positive cases (P=۰.۰۳۹).Conclusion: In the present study, we introduced KINDLIN۱ as a location-specific marker for cardia gastric carcinoma. Moreover, it was observed that KINDLIN۱ could be used as a sex-dependent diagnostic marker of GC patients.

Authors

Mohammad Reza Abbaszadegan

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Negin Taghehchian

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

Azadeh Aarabi

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Sohrab Nozari

Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ehsan Saburi

Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Meysam Moghbeli

Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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