Ghrelin Is Effective on Passive Avoidance Memory by Altering the Expression of NMDAR and HTR۱a Genes in the Hippocampus of Male Wistar Rats

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_RBMB-10-3_005

تاریخ نمایه سازی: 25 بهمن 1400

Abstract:

Background: Memory-dependent psychological behaviors have an important role in life. Memory strengthening in adulthood to prevent its defects in aging is a significant issue. The ghrelin endogenous hormone improves memory by targeting glutamatergic and serotonergic circuits. Also, citicoline, a memory strengthening drug in aging, is not recommended to adults due to its side effects. The current study aims to test that ghrelin treatment, like citicoline, would improve passive avoidance memory via expression of the genes encoding the N-methyl-D-aspartate receptor (NMDAR۱) and the serotonin receptor ۱A (HTR۱a) involved in this process. Methods: Five groups of adult male rats received (۱) saline (as control), (۲) ۰.۵ mg/kg citicoline, or (۳-۵) ۰.۳, ۱.۵, and ۳ nmol/μl ghrelin). The rats received the drugs via intra-hippocampal injection. Passive avoidance memory was determined using a shuttle box device. The latency to enter the dark chamber before (IL) and after (RL) injection and the total duration of the animal's presence in the light compartment (TLC) were evaluated. Then, the gene expression rates of NMDAR۱ and HTR۱a were measured by the Real-Time PCR.  Results: Ghrelin and citicoline had some similar and significant effects on passive avoidance memory, and both increased NMDAR۱ and decreased HTR۱a expression.  Conclusions: Ghrelin, like citicoline, improves passive avoidance learning by altering the NMDAR۱ and HTR۱a expression in the hippocampus.

Authors

Vahideh Sahraiian

Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

Homayoun Khazali

Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.

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  • Hansson C, Haage D, Taube M, Egecioglu E, Salomé N, ...
  • Morin V, Hozer F, Costemale-Lacoste JF. The effects of ghrelin ...
  • Mahmoudi F, Mohsennezhad F, Khazali H, Ehtesham H. The effect ...
  • Matyja E, Taraszewska A, Nagańska E, Grieb P, Rafałowska J. ...
  • Petkov VD, Mosharrof AH, Kehayov R, Petkov VV, Konstantinova E, ...
  • Teather LA, Wurtman RJ. Dietary CDP-choline supplementation prevents memory impairment ...
  • Li F, Tsien JZ. Memory and the NMDA receptors. N ...
  • Ogundele OM, Nanakumo ET, Ishola AO, Obende OM, Enye LA, ...
  • Albert PR, Fiori LM. Transcriptional dys-regulation in anxiety and major ...
  • Akbari-Fakhrabadi M, Najafi M, Mortazavian S, Memari A-H, Shidfar F, ...
  • Carlini VP, Monzón ME, Varas MM, Cragnolini AB, Schiöth HB, ...
  • Xu F, Hongbin H, Yan J, Chen H, He Q, ...
  • Carlini VP, Varas MM, Cragnolini AB, Schiöth HB, Scimonelli TN, ...
  • Paxinos G, Watson C. The rat brain in stereotaxic coordinates. ...
  • Babri S, Badie HG, Khamenei S, Seyedlar MO. Intrahippocampal insulin ...
  • Bavarsad K, Hadjzadeh MA, Hosseini M, Pakdel R, Beheshti F, ...
  • Lohman RJ, Liu L, Morris M, O'Brien TJ. Validation of ...
  • Rezayof A, Habibi P, Zarrindast MR. Involvement of dopaminergic and ...
  • Bustin SA. Absolute quantification of mRNA using real-time reverse transcription ...
  • Mo Y, Wan R, Zhang Q. Application of reverse transcription-PCR ...
  • Muniz BG, Isokawa M. Ghrelin receptor activity amplifies hippocampal N-methyl-d-aspartate ...
  • Berrout L, Isokawa M. Ghrelin upregulates the phosphorylation of the ...
  • Secades JJ. Citicoline: pharmacological and clinical review, ۲۰۱۰ update. Rev ...
  • Danysz W, Parsons CG. Alzheimer's disease, β-amyloid, glutamate, NMDA receptors ...
  • Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekström JC, ...
  • Pitsikas N, Tsitsirigou S, Zisopoulou S, Sakellaridis N. The ۵-HT۱A ...
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