A Genetic Variant in Proline and Serine Rich Coiled-Coil ۱ Gene Is Associated with the Risk of Cardiovascular Disease

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_RBMB-10-4_015

تاریخ نمایه سازی: 25 بهمن 1400

Abstract:

Background: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil ۱ gene in ۱p۱۳.۳ locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs۵۹۹۸۳۹ polymorphism of the Proline and Serine Rich Coiled-Coil ۱ (PSRC۱) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort. Methods: Five hundred and nine individuals who had an average follow-up period of ۱۰ years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method. Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= ۴.۷; ۹۵% CI, ۲.۵-۸.۷; p< ۰.۰۰۱) in comparison to those with AA genotype; however, the result was not significant for GG genotype data. Conclusions: The results suggest that the GA/GG genotypes of the PSRC۱gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.

Authors

Mohammad Sadegh Khorrami

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Metabolic Syndrome

Fatemeh Sadabadi

Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Alireza Pasdar

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Hamide Safarian-Bana

Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Forouzan Amerizadeh

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Habibollah Esmaeily

Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Epidemiology and Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohsen Moohebati

Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Alireza Heidari-Bakavoli

Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Gordon Ferns

Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, UK.

Majid Ghayour-Mobarhan

Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Amir Avan

Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran & Metabolic Syndrome

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