Synthesis, Characterization and Antimicrobial Activity of Cu(II), Pt(IV) and Au(III) Complexes with ۲,۶-bis(((۱-decyl-۱H-۱,۲,۳-triazole-۴-yl)methoxy)methyl)pyridine

In this work, ۲,۶-bis(((۱-decyl-۱H-۱,۲,۳-triazole-۴-yl)methoxy)methyl)pyridine was prepared by click reactions between ۲,۶-bis((prop-۲-yn-۱-yloxy) methyl) pyridine and ۱-azidodecane catalyzed by cuprous ion, then used as ligand in complexation reaction with some metal ions [Cu(II), Pt(IV) , and Au(III)]. The prepared ligand chelates N۲O۲ with copper (II) and Gold (III), as well as N۳O۲ with Platinum (IV). Characterized by [Flame-AAS, C.H.N. analysis, ۱H-۱۳C-NMR, Mass Spectroscopy, UV/Vis, FT-IR, conductivity, and magnetic susceptibility] were used to describe these compounds in the solid-state. The L-Cu and L-Au complexes have square planer geometry, while the L-Pt complex has octahedral geometry. The biological behaviors as antibacterial (against Staphylococcus aureus, and Escherichia coli) and antifungal (against candida albicaus) of the prepared ligand with its complexes were tested in different concentrations (۱۰, ۵۰, ۲۰۰) ppm after incubation at ۳۷ºC for ۲۴h.The results showed that the performance of the prepared compounds was better in resisting and inhibiting the growth of tested bacteria and fungi at high concentrations and that the gold complex was more synergetic effective than others.

Keywords:

Metal-ligand complexation , Triazole derivatives , Antimicrobial activity