The Evaluation of Clinical and Paraclinical (Laboratory or ECG) in Methadone Toxication

BackgroundNowadays, drug abuse is increasing globally, and methadone toxicity, which is also available as addiction treatment, has also increased. Therefore, due to the increased availability of methadone and the novelty of its toxication phenomena, this study aimed to determine the prevalence of methadone toxicity and its Clinical laboratory findings was done.Materials and MethodsIn this study, the cases of ۲۱۴ patients who had referred to RaziHospital in Guilan province due to methadone toxication were investigated. The researcher recorded the necessary information through the patients' files. Analyzing the collected data using SPSS software version ۱۹ and using central indicators and dispersion of statistics, including Mean, standard deviation and statistical samples, were estimated significantly (P <۰.۰۵).Ethical ConsiderationsHonesty and fidelity in writing the text have been observed.FindingsIn this study, the patients' mean age was ۳۰.۵۲ years and ۷۵% of the male patients. Nearly ۴۰% of the patients were drug addicts, ۲۵.۵% of the addicts were under the supervision of methadone maintenance centres, and ۳۴.۵% were none addicted. The average dose of methadone in these cases was ۳۵.۵±۳۵.۷ mg. The most common clinical finding was respiratory depression and then decreased consciousness. The most common result of the ECG in these patients was prolonged QT. ۳۴.۶% of the patients had high SGPT.ConclusionMethadone toxicity can lead to serious clinical and Para clinical symptoms that require accurate and comprehensive evaluations to reduce these complications.

Keywords:

Methadone , Toxicity , heart disease