Investigation on the Relationship between D-Dimer and Cell Blood Count Indices in COVID-۱۹ Prognosis: A Retrospective Study on ۳۲۰ COVID-۱۹ Patients

Introduction:Due to the spreading of coronavirus infection in ۲۰۱۹ (COVID-۱۹) throughout the world, tracking cell blood count (CBC) of moderate to severe COVID-۱۹ patients could provide new insights for the prognosis prediction.Materials and Methods: In this observational-retrospective study, D-dimer and CBC documents of ۳۲۰ confirmed COVID-۱۹ patients hospitalized in Shamsoshomus Clinic, Mashhad, Iran, were evaluated. Receiver operation characteristics (ROC) curve was analysed to determine specificity and sensitivity of D-dimer and hematological indices, including white blood cell (WBCs), lymphocytes, monocytes, eosinophil, red blood cell width (RDW), platelets (PLT), and mean of platelet volume (MPV). Results: This study included ۱۵۷ (۴۹.۱%) male and ۱۶۳ (۵۰.۳%) female COVID-۱۹ patients between ۱۴ to ۹۶ years old. According to their status in the duration of hospitalization, patients were considered in the good outcome group (N=۲۱۵) and poor outcome group (N=۱۰۵). A significant difference was observed in D-dimer, WBCS, PMN, Lymph, monocytes, eosinophil, and RDW between the two groups (P<۰.۰۰۱). The highest sensitivity and the lowest specificity belonged to RDW (۹۹%, ۴%), WBCs (۹۸%, ۴%), PMN (۹۹%, ۱۱%) and D-dimer (۹۶%, ۴۲%). D-dimer indicated a significant association with WBCs, PMN, and RDW (P<۰.۰۵).Conclusion:The present study revealed that WBCs and RDW might be recommended for the COVID-۱۹ prognosis prediction due to their high comparable sensitivity to D-dimer.

Keywords:

Cell Blood count , COVID-۱۹ , Prognosis Red blood cell width , white blood cell , sensitivity , specificity