Review on role alkyne and azide building blocks for click chemistry in organic synthesis and their application

Click chemistry is a powerful, high-fidelity technology of organic reactions that involves the rapid and efficient covalent coupling of two or more functional chemical entities to form diverse heterocycles under environmentally acceptable conditions. Click reactions are characterized to give a single product, high economy, high and pure. We have discussed many elements of click reactions in organic synthesis because they are essential and useful in drug discovery, supramolecular chemistry, materials science, and nanotechnology. Azide-alkyne cycloaddition (AAC) is an essential technique with the reaction of the trephine between the azide group and the alkene based on Cu(I) ions and nanoparticles. Over the last years, using catalyst transition metal of novel methods in click chemistry reactions with applications in materials, drug, and biological activity has been increased significantly.

Keywords:

Click reaction Organic synthesis Azide , alkyne Atomic economy