Immunopathogenesis of endometriosis; an overview of the role of innate and adaptive immune cells and their mediators

Publish Year: 1400
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

ICMWMI06_027

تاریخ نمایه سازی: 15 فروردین 1401

Abstract:

Endometriosis is a chronic inflammatory disease associated with the growth and proliferation of endometrial-like tissues outside the uterus. Although the exact etiology and mechanism of the pathogenesis of the disease have not been fully elucidated, the immune system cells and the mediators produced by them can be named as effective factors in the onset and progression of the disease. Abundant production of inflammatory mediators by neutrophils and macrophages and reduced cytotoxicity of defined cells promote endometriosis at the early stages of the disease. Following an increase in the inflammation of the environment, the body takes compensatory mechanisms to reduce inflammation and establish homeostasis. For this purpose, the body produces remodeling and anti-inflammatory factors leading to slow conversion of the inflammatory environment into a non-inflammatory environment with proliferative and immunosuppressive properties. Environmental conditions induce M۲ macrophages, TH۲ cells, and Tregs differentiation, promoting disease progression by producing angiogenic and immunosuppressive factors. However, the exact molecular mechanism involved in changing inflammatory to non-inflammatory conditions is not yet fully understood. In this study, we attempted to review studies on the role of the immune system in endometriosis to better understand the pathogenesis of endometriosis.

Keywords:

Endometriosis. Adaptive immunity. Innate immunity. Immune cell. Mediator

Authors

Maryam Zare Moghaddam

Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences,

Hossein Ansariniya

Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Seyed Mohammad Seifati

Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Fateme Zare

Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Farzaneh Fesahat

Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran