Synthesis of New Schiff Base from Antibiotics and Some of Its Metal Complexes with Study Some of Their Applications

Synthesis of new Schiff base ligand (L) from sulfamethoxazole with tenoxicam in mole ratio ۱:۱. The metal complexes were synthesized by the reaction of (CoCl۲.۶H۲O, NiCl۲.۶H۲O CuCl۲ .۲H۲O) with Ligand in mole ratio ۲:۱ (L:M). The characterization of all synthesized compounds carried out by spectral methods such as ultra violet and visible radiation (UV-Vis), infrared (FT-IR), nuclear magnetic resonance of protons (۱H-NMR), thermal analyses (TG, DTG) and atomic absorption (AAS) as well as melting point (m.p) measurement, micro elemental analysis (CHNS), magnetic susceptibility measurement and determination of chloride content. The suggested geometries of all complexes were octahedral. All complexes were electrolyte and paramagnetic. All of the synthesized compounds were found to be anti-bacterial and anti-fungal against bacteria Klebsiella pneumonia (G-) and Staphylococcus aurus (G+) as well as fungi rizopussporium. Also anti-cancer property of the ligand was tested.

Keywords:

Schiff base , Sulfamethoxazole , Tenoxicam