An Investigation of the Relationship between Beta-۲ Microglobulin (β۲M) and Inflammatory Factors (Serum Levels of CRP and Albumin) and High Density Lipoproteins (HDL) in Hemodialysis Patients

Background and Objective: Beta-۲ Microglobulin (β۲M) is a middle molecular weight uremic toxin. Lack of β۲M removal leads to β۲M accumulation and amyloidosis in hemodialysis patients. The present research aims to determine the relationship between β۲M and inflammatory factors, such as C-reactive protein (CRP), albumin, and high-density lipoprotein (HDL) in hemodialysis patients.  Methods: Fifty-four hemodialysis patients were selected and their pre- and post-dialysis serum levels of β۲M, CRP, albumin, and HDL, were measured. Results: There was an obvious inverse relationship between β۲M level and serum level of albumin, while no relationship was found between β۲M and CRP or HDL. Conclusion: According to the findings of this study, it was identified that inflammatory-induced increase in β۲M level in dialysis patients leads to reduced serum albumin

Keywords:

Beta-۲ Microglobulin , albumin , hemodialysis , inflammation.